Novel Organo Phosphonate-1,2,3 Triazole Derivatives: Molecular Properties Prediction
Jhonsee Rani Telu
Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India.
Naveen Kuntala
Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India.
Jaya Shree Anireddy
Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India.
Sarbani Pal *
Department of Chemistry, MNR Degree & PG College, Kukatpally, Hyderabad-500072, India.
*Author to whom correspondence should be addressed.
Abstract
In the present scenario drug discovery and development processes are expensive and time consuming. To resolve this, we utilised the Lipinski’s rule (Ro5) methodology, which appears to be useful in defining drugability. In the present investigation, we reported the synthesis and evolution of antibacterial activity of title compounds and according to Rule of 5 series, twenty novel ((R)-dimethyl (hydroxy(4-((1-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)methyl)phosphonate-1,2,3-triazole derivatives were subjected to molecular properties prediction, drug likeness by Molinspiration (Molinspiration, 2020) and Molsoft (Molsoft, 2020) software.
Keywords: Organo phosphorous triazoles, azide-alkyne cycloaddition, molinspiration, molsoft.