Synthesis, Crystal Structure and Interaction with Bovine Serum Albumin (BSA) of Two α-Aminophosphonic Acids Derivatives
Wei Huang
School of Pharmacy, Yancheng Teachers’ University, Yancheng, 224051, People’s Republic of China.
Wen-Ling Wang *
School of Pharmacy, Yancheng Teachers’ University, Yancheng, 224051, People’s Republic of China.
*Author to whom correspondence should be addressed.
Abstract
Two α-amino-phosphonate derivatives (1 & 2) were synthesized and their compositions and structures were characterized by Elemental Analysis (EA), FT-IR Spectrascopy (FT-IR), Electrospray Ionization Mass Spectrometry (ESI-MS), Nuclear Magnetic Resonance (NMR, 1H, 13C and 31P) and X-ray crystallography. Compound 1 & 2 were crystallized in monoclinic system with the space group P2(1)/n and P2(1)/c, respectively. The interaction effects of two α-aminophosphonate derivatives (1 & 2) with BSA were investigated and the binding constants were 1.07 × 104 M-1, 1.68 × 104 M-1, respectively. Besides, the values of n were indicated that 1:1 complex was formed between BSA and 1&2.
Keywords: α-amino-phosphonate derivatives, characterizations, crystal structure, interaction, BSA.