1-Tosyl-2-trifluoroacetylindole as Promising Partner for Synthesis of Fused Fluorinated Heterocycles
Konstantin S. Chunikhin *
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Russia.
*Author to whom correspondence should be addressed.
Abstract
We prepared 1-tosyl-2-trifluoroacetylindole - a novel example of an electron-deficient indole with an electrophilic C(3) position. This substance was involved in cyclocondensation with a variety of amidines to propose a new general pathway to 8H-[4,5-b]indolopyrimidines with yield 50-80%. CF3-containing 5H-[3,2-d]indolopyrimidines were unknown before this study.
Keywords: Electron-deficient indole, amidines, indolopyrimidines, electrophiles, nucleophiles, fluorine