Synthesis, Characterization and DNA Binding Studies of (E)-1-((Pyridin-2-yl)methylidene) semicarbazide Mn(II), Co(II), Ni(II) and Cu(II) Complexes
Oinam U-wang
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
R. K. Bhubon Singh *
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
W. Bembee Devi
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
U. Ibotomba Singh
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
R. K. Bindiya Devi
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
O. Bijeta Devi
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
Ramina .
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
Th. Surchandra Singh
Department of Chemistry, Manipur University, Canchipur- 795003, Manipur, India.
Toka Swu
Department of Chemistry, Pondicherry University, R.V. Nagar, Kalapet, Puducherry 605014, India.
*Author to whom correspondence should be addressed.
Abstract
(E)-1-((pyridin-2-yl)methylidene)semicarbazide (PMSC) complexes of [Mn(PMSC)2 ]Cl2 (1), [Co(PMSC)2]Cl2 (2), [Ni(PMSC)2]Cl2.5H2O (3), and [Cu(PMSC)(H2O)]Cl2 (4) have been synthesized and characterized by different spectroscopic techniques, EPR, magnetic susceptibility and thermal stability measurements. Complex 3 crystallizes as octahedral coordination complex in monoclinic crystal system. Complexes 1 and 2 have been found to have octahedral geometries and 4 to have square planar geometry. The complexes were found to be groove binding to calf-thymus DNA.
Keywords: Schiff base, complex, DNA, groove binding.