A Facile Synthesis of 7-amino-1,3-diaryl-5-phenyl-2-thioxo-pyrano[2,3-d]pyrimidine-4(5H)-ones
Nimalini Moirangthem
Department of Chemistry, Manipur University, Canchipur- 795 003, India.
Warjeet S. Laitonjam *
Department of Chemistry, Manipur University, Canchipur- 795 003, India.
*Author to whom correspondence should be addressed.
Abstract
The reactions of arylidene derivatives such as ethylphenylmethylenemalononitrile 3a, ethylphenylmethylenecyanoacetate 3b and ethylphenylmethylenecyano-acetamide 3c with substituted thiobarbituric acids 2a-e in presence of NaOCH3 and MeOH afforded 7-amino-1,3-diaryl-5-phenyl-2-thioxo-pyrano[2,3-d]pyrimidin-4(5H)ones 4a-e and 5e by cyclocondensation.
Keywords: Synthesis, pyranopyrimidines, thiobarbituric acids, arylidenes