Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives
Olayinka O. Ajani *
Department of Chemistry, School of Natural and Applied Sciences, Covenant University, P.M.B. 1023, Ota, Ogun State 1100001, Nigeria
Oluwole B. Familoni
Department of Chemistry, University of Lagos, Akoka, Lagos State 10001, Nigeria
Johnbull O. Echeme
Department of Chemistry, School of Natural and Applied Sciences, Covenant University, P.M.B. 1023, Ota, Ogun State 1100001, Nigeria
Feipeng Wu
New Functional Polymeric Material Group, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, P.R. China
Zheng Sujiang
Test Center of Antimicrobial Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, P.R. China
*Author to whom correspondence should be addressed.
Abstract
Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was N,N-diethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).
Keywords: 2-(Phenylsulfonamido) acetic acid, inhibition zone, N,N-diethylamide, antibacterial study, streptomycin