Synthesis and Studies on Some Spiro and Fused of Quinone Derivatives
H. A. Soleiman *
Chemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
A. K. Khalafallah
Chemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
A. M. H. Sorry
Chemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
*Author to whom correspondence should be addressed.
Abstract
Some new Spiro β-lactam, Spiro thiazolidine derivatives were synthesized by the reaction of new Schiff bases (5a-c, 8a-c ) with chloroacetyl chloride and/or mercaptoacetic acid to give new Spiro β-lactam (6a-c, 9a-c ) and new Spiro thiazolidinone derivatives (7a-c, 10a-c ) . Also, new fused pyrazolo derivatives (12a-c, 13a-c) fused isoxazolo derivatives (14a-c) and pyrimidine derivatives (15a-c, 16a-c) were synthesized by the reaction of new arylidine derivatives (11a-c) with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, urea and thiourea, respectively.
Keywords: Spiro β-lactam, spiro thiazolidinone, fused pyrazoles, fused isoxazole, fused pyrimidine's