Synthesis and Antimicrobial Activities of Novel Aminoalkylated 2H-benzotriazoles
Bharti Bhardwaj *
Department of Chemistry, University of Delhi, Delhi-110 007, India
Subhash C. Jain
Department of Chemistry, University of Delhi, Delhi-110 007, India
*Author to whom correspondence should be addressed.
Abstract
In view of generating new compounds for future drug development, we have synthesized some N-aminoalkylated derivatives of benzo[d][1,2,3]triazole by alkylating benzo[d][1,2,3]triazole in the presence of K2CO3/DMF using 1,6-dibromohexane to obtain the 2-(6-bromohexyl)-2H-benzo[d][1,2,3]triazole (3) as the one of the major product which was then used as an intermediate to synthesize a new series of compounds 4a-j. All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities In vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermis), four Gram-negative bacteria (Echerichia coli, Pseudomonas aeuroginosa, Staphylococcus typhi and Klebsiella pneumoniae) and four fungi (Aspergillus niger, Aspergillus fumigatus, Candida albicans and Aspergillus flavus) strains using Cup plate method.
Keywords: Antimicrobial activity, benzo[d][1,2,3]triazole, 1,6-dibromohexane, aliphatic/ heterocyclic secondary amines