Synthesis of Novel Methylidene Bridged Quinazoline-Isoquinoline Alkaloids
Sherzod N. Zhurakulov
Laboratory of Alkaloid’s Chemistry, Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 100170, Uzbekistan
Burkhon Zh. Elmuradov *
Department of Organic Synthesis, Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 100170, Uzbekistan
Valentina I. Vinogradova
Laboratory of Alkaloid’s Chemistry, Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 100170, Uzbekistan
*Author to whom correspondence should be addressed.
Abstract
Interaction of 3-hydroxymethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazolin-9-one (2) with 1H(aryl)-6,7-dimethoxytetrahydroisoquinolines (3a-f) leads to the formation of novel methylidene bridged quinazoline-isoquinoline alkaloids. By results of IR- and 1Н-NMR – spectroscopy are shown that the synthesized products have enamine form and E-configuration.
Keywords: 3-hydroxymethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazolin-9-one, 1H(aryl)-6,7-dimethoxytetrahydroisoquinolines, nucleophilic substitution reactions, E-configuration