The Synthesis of Atomoxetine-containing Carboxamides - Potential Human Carbonic Anhydrase Inhibitors
Anton A. Shetnev *
Yaroslavl State Pedagogical University Named After K. D. Ushinsky, 108 Respublikanskaya st, Yaroslavl, 150000, Russia
Angelina T. Osipyan
Yaroslavl State Pedagogical University Named After K. D. Ushinsky, 108 Respublikanskaya st, Yaroslavl, 150000, Russia
Alexander V. Sapegin
Yaroslavl State Pedagogical University Named After K. D. Ushinsky, 108 Respublikanskaya st, Yaroslavl, 150000, Russia
Mikhail V. Dorogov
Yaroslavl State Pedagogical University Named After K. D. Ushinsky, 108 Respublikanskaya st, Yaroslavl, 150000, Russia
*Author to whom correspondence should be addressed.
Abstract
The method of synthesis of Atomoxetine is developed, including enzyme-catalyzed stereospecific reduction 3-chloro-1-phenyl-propan-1-one and Mitsunobu condensation with a chiral alcohol, and o-cresol. New potential human carbonic anhydrase inhibitors were obtained via reaction Atomoxetine with carboxylic derivatives of benzene and thiophene containing primary sulfonamide moiety.
Keywords: Atomoxetine, sulfonamides, amide formation, biologically-active compounds, carbonic anhydrase inhibitor