Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters
Dorothée D. Tshilanda
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Koto-te-Nyiwa Ngbolua
Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Damien S. T. Tshibangu
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Augustin M. Malumba
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Pius T. Mpiana *
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
*Author to whom correspondence should be addressed.
Abstract
Organic acids and their derivatives like butyl stearate have recently shown antisickling activity. Some none aromatic esters were synthetized and tested for their antisickling activity using Emmel test. On 21 esters tested only three showed no antisickling activity. Butyl palmitate, propyl palmitate, butyl stearate, propyl stearate and methyl nonadecanoate showed interesting antisickling activity with a normalization rate higher than 70%.
Keywords: Non- aromatic esters, antisickling activity, synthesis, butyl stearate