Synthesis, Characterization and Antimicrobial Activity of Some New Heterocyclic Compounds Incorporating Pyridazine Moiety
Fekria M. A. Soliman
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Nadia T. A. Dawoud *
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Nahed F. Abdel-Ghaffar
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Marwa I. El-Guindy
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Heba Naguib
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
*Author to whom correspondence should be addressed.
Abstract
A series of heterocyclic compounds incorporating pyridazine moiety (1-24) were synthesized and evaluated for antimicrobial activities Gram- positive bacteria, Gram- negative bacteria and Yeast. Compounds 2b, 2c, 6, 7 and 10 were tested under antimicrobial activities as MICS. The results illustrated that among the synthesized compounds as a lead compound with good antimicrobial activity.
Keywords: Pyridazine, α,- unsaturated compounds, antimicrobial activity