Synthesis and Biological Activity of Novel 5-(Alkylthio)-1,3,4-thiadiazol-2(3H)-thione Derivatives
Elen N. Hambardzumyan
Laboratory of Plant Protection and Pesticides Synthesis, Armenian National Agrarian University, 34 Teryan Str., Yerevan, 0009, Armenia
Asya S. Vorskanyan
Laboratory of Plant Protection and Pesticides Synthesis, Armenian National Agrarian University, 34 Teryan Str., Yerevan, 0009, Armenia
Ani A. Grigoryan *
Department of Chemistry, Russian-Armenian (Slavonic) State University, 123 H. Emin Str., Yerevan, 0051, Armenia
Aleksandr P. Yengoyan
Laboratory of Plant Protection and Pesticides Synthesis, Armenian National Agrarian University, 34 Teryan Str., Yerevan, 0009, Armenia and Department of Chemistry, Russian-Armenian (Slavonic) State University, 123 H. Emin Str., Yerevan, 0051, Armenia
*Author to whom correspondence should be addressed.
Abstract
Some nonfused biheterocyclic system derivatives containing a combination of 1,3,4-thiadiazole and pharmacophores such as 1,3,4-oxadiazole and/or pyrazoles in the same molecule were obtained based on 2-((5-(alkylthio)-1,3,4-thiadiazol-2-yl)thio)acetohydrazide. The synthesized compounds show pronounced plant growth stimulant properties.
Keywords: 5-(alkylthio)-1,3,4-thiadiazole-2(3H)-thiones derivatives, heterocyclization, nonfused biheterocyclic systems, 1,3,4-oxadiazole, pyrazole, plant growth stimulant properties