Synthesis, Spectroscopic Studies and Antimicrobial Activity of Novel Aromatic Hydrazones Derived from 1-Hydralazinophthalazine
Joseph N. Yong *
Department of Chemistry, University of Buea, P.O.Box 63, Buea, SWR, Cameroon
Peter F. Asobo
Department of Chemistry, Higher Teacher’s Training College, University of Bamenda, P.O.Box 63, Bambili, NWR, Cameroon
Kennedy D. Nyongbela
Department of Chemistry, University of Buea, P.O.Box 63, Buea, SWR, Cameroon
Romanus N. Njong
Department of Chemistry, University of Buea, P.O.Box 63, Buea, SWR, Cameroon
Oswald N. Nfor
Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung City, 40201, Taiwan
*Author to whom correspondence should be addressed.
Abstract
Aims: To synthesize novel Schiff bases, determine their structures by spectroscopic methods including IR, 1H and 13C NMR, single crystal X-ray diffraction and elemental analysis and test them against some selected bacterial strains.
Methodology: 1-Hydralazinophthalazine was condensed with 5-methylfurfural and 2-acetylthiophene to form hydrazones. The Schiff bases obtained were screened for antimicrobial activity using the agar-diffusion method.
Results: The spectroscopic data indicate the presence an exocyclic C=N and an N-H bond on the hydralazine moiety of the Schiff base. These compounds show moderate activity against the selected bacterial strains
Conclusion: Two new Schiff bases were derived from hydralazine hydrochloride and their structures were determined by elemental analysis, single X-ray diffraction method, IR and NMR. These compounds showed moderate antimicrobial activity against some selected bacterial strains compared to amoxicillin and norfloxacin as standards.
Keywords: Schiff bases, hydrazones, single crystal, antibacterial