Synthesis of Novel Derivatives on the Basis of 4-Hydrazinyl-6-methyl-2-(alkylthio)pyrimidines and Their Preliminary Biological Evaluation
Vergush A. Pivazyan
Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia
Emma A. Ghazaryan
Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia
Roza S. Shainova
Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia and Department of Chemistry, Russian-Armenian (Slavonic) State University, 123 H. Emin str., Yerevan, 0051, Armenia
Rafael A. Tavalyan
STC OPC Molecule Structure Research Center NAS RA, Yerevan, Armenia, 26 Azatutyan av., Yerevan, 0014, Armenia
Armen G. Ayvazyan
STC OPC Molecule Structure Research Center NAS RA, Yerevan, Armenia, 26 Azatutyan av., Yerevan, 0014, Armenia
Aleksandr P. Yengoyan *
Laboratory of Plant Protection and Pesticides Synthesis, National Agrarian University of Armenia, 34 Teryan str., Yerevan, 0009, Armenia and Department of Chemistry, Russian-Armenian (Slavonic) State University, 123 H. Emin str., Yerevan, 0051, Armenia
*Author to whom correspondence should be addressed.
Abstract
By functionalization of 4-hydrazinyl-6-methyl-2-(alkylthio)pyrimidines the corresponding acetohydrazides, N-phenylhydrazine-1-carboxamides(thioamides) were obtained. The heterocyclization of the same hydrazides lead to nonfused pyrazolyl-pyrimidines and pyridazinyl-pyrimidines and a series of 3-S-substituted derivatives of fused 1,2,4-triazolo[4,3-c]pyrimidine. The preliminary in vitro tests have shown that among the synthesized compounds there are substances exhibiting growth promoting properties.
Keywords: 4-hydrazinyl-6-methyl-2-(alkylthio)pyrimidines, N-phenylhydrazine-1-carboxamides and thioamides, heterocyclization, pyrazolyl-pyrimidines, pyridazinyl-pyrimidines, 1,2,4-triazolo[4,3-c]pyrimidines, growth stimulant activity