Chemical Science International Journal

Synthesis, Characterization, and Biological Evaluation of Two Hydrazone Schiff Base Ligands and their Transition Metal Complexes

Abdoul Sall

Département de Chimie, Université Alioune Diop de Bambey, Sénégal.

Fatma Yatté

Département de Chimie, Université Alioune Diop de Bambey, Sénégal.

Antoine Blaise Kama

Département de Chimie, Université Alioune Diop de Bambey, Sénégal.

Farba Bouyagui Tamboura

Département de Chimie, Université Alioune Diop de Bambey, Sénégal.

Moussa Dieng *

Département de Chimie, Université Alioune Diop de Bambey, Sénégal.

Mohamed Gaye

Département de Chimie, Université Cheikh Anta Diop de Dakar, Sénégal.

*Author to whom correspondence should be addressed.

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Abstract

Schiff bases are widely employed as chelating ligands in coordination chemistry, and their metals complexes have been extensively studied because of their potential applications. N, N-donor Schiff bases ligands are know to form series of transition-metal complexes display interesting structures antioxidant and antibacterial propreties. In this work, two new ligands and their corresponding complexes are prepared. The two ligands are structurally characterized by elemental analysis, infrared, NMR and UV-Vis spectroscopy as well as molar conductance measurements. Ligand H₂LA is obtained from the condensation of 5-bromo-2-hydroxyacetophenone with nicotinohydrazide whereas ligand H₂LB is synthesized from 4-hydroxy-3-methoxybenzaldehyde and nicotinohydrazide. Two water molecules are associed with H₂LB. In this paper the antibacterial activities of the ligands are investigated. Ligand H₂LB crystallizes in the monoclinic system, space group P2₁/c with the unit cell parameters a = 7.9079(2) Å, b = 27.5162(6) Å, c = 6.9736(2) Å, α = 90°, β = 110.495(3) °, γ = 90°.

Keywords: Metal complexes, UV, ligands, biological

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